IRF3 and infection: To further examine the interactions of PTK2B with STING, TBK1 and IRF3, we next performed endogenous Co-IP experiments with PTK2B antibody in RAW 264.7 cells with or without HSV1-GFP infection and found that PTK2B only pulled down STING and TBK1 regardless of the HSV1-GFP infection state (Fig. 1c).