Consistently, PTK2B overexpression not only augmented the levels of phosphorylated STING, TBK1 and IRF3 induced by HSV1-GFP infection but also increased the levels of phosphorylated TBK1 and IRF3 induced by VSVΔM51-GFP infection (Supplementary Fig. S3e, f). The gene discussed is IRF3; the disease is infection.