As seen in Fig. 5, the mRNA expression of Crh (MdnSHAM=1, MdnCKD=2.065, U=7, p=0.0090), Crhr1 (MdnSHAM=1, MdnCKD=1.390, U=0, p=0.0002), and Crhr2 (MdnSHAM=1, MdnCKD=1.429, U=0, p=0.0079) in the amygdala was significantly higher in the CKD group than in the sham-operated group, whereas Avp expression (MdnSHAM=1, MdnCKD=0.47, U=16, p=0.1462) was not affected significantly by the 5/6 nephrectomy. The gene discussed is CRH; the disease is chronic kidney disease.