As HPA axis activation has been implicated in both CKD and anxiety, the expression of arginine vasopressin (Avp), corticotropin-releasing hormone (Crh), and CRH receptor 1 (Crhr1) and 2 (Crhr2) genes was determined in the amygdala, followed by analysis of protein expression. The gene discussed is CRHR2; the disease is Anxiety.