In the amygdala (Fig. 6), no significant difference was found in the protein expression of CRH (MSHAM =0.4747, MCKD =0.4413, t(17.23)=1.251, p=0.2276), CRHR1 (MSHAM =0.3417, MCKD =0.3379, t(22)=0.2684, p=0.7909) and CRHR2 (MSHAM=0.5737, MCKD =0.5503, t(17.23)=1.302, p=0.2070) between the sham-operated and CKD groups. This evidence concerns the gene CRHR1 and chronic kidney disease.