HOXA11 and cancer: Although, BBI608, could shrink the peritoneal disseminated tumor volume shaped by HOXA11 over-expressed GC cells, the remnant tumor was engulfed by mesothelium [1], BBI608 mainly targets the “seeds” (that is, cancer cells themselves), while effective antimetastatic responses could also be fulfilled by delivery of drugs that change the “soil” of the peritoneal tissue microenvironments [14], which inspired our desire to investigate the “soil” of TME in the peritoneum.