As emerging and accumulating evidence had found that cytokines are the key cues for illustrating the molecular basis underlying the intercellular communications in the tumor microenvironment [18, 19], we supposed that PDGF BB and TGF β1 which released by HOXA11 over-expressed GC cells confer the mesothelial fibrosis in the co-culture system. Here, HOXA11 is linked to neoplasm.