It is noteworthy that several proteins, including ACTC1, EFNB2, F2RL1, MME, P4HA1, SPP1, STC2, THBS1, and LAMC2, were found to be significantly overexpressed in the tumor tissues of HNSCC compared to normal tissues. This evidence concerns the gene F2RL1 and head and neck squamous cell carcinoma.