Specifically, upregulated proteins, including PFKP, SLC16A1, KDSR, LPCAT3 and CDIPT, as well as downregulated proteins, including HAAO, GOT2, FABP3, IDH3G and GLYCTK caused by SETD2 deletion in mice, were also consistently increased or decreased respectively in human ccRCC (Fig. 5b). Here, IDH3G is linked to nonpapillary renal cell carcinoma.