SETD2 and nonpapillary renal cell carcinoma: To further examine the clinical functional relevance between SETD2 and SM biosynthesis, we analyzed transcriptomic and proteomic signatures in ccRCC patients from The Cancer Genome Atlas (TCGA) database (n = 533) and The Clinical Proteomic Tumor Analysis Consortium (CPTAC) database (n = 606), respectively.