Recently, we carried out functional phenotyping of γδTILs of HCC patients by scRNA-seq and found low IL17A but high IFNG expression in γδTILs (mostly Vδ1+), implying cytotoxic effector function of γδTILs in HCC.243 Since γδ T cells display heterogeneity across cancer types or even among individuals, more sophisticated and thorough studies are needed to truly shed light on the functional discrepancies and plasticity of γδ T cells and facilitate their clinical applications. This evidence concerns the gene IFNG and cancer.