They contribute to tissue inflammation and immune dysregulation in conditions like autoimmune disorders.7,20 In infections, they actively participate in pathogen clearance by producing IL-17, IFN-γ, and other proinflammatory cytokines, while activating immune cells such as macrophages and neutrophils.57,59,346 However, dysregulated activation of γδT17 cells can lead to tissue damage71,347 and chronic inflammation,309 even autoimmune diseases like psoriasis.69,313,348 Understanding their intricate regulation network is important for developing effective treatment regiments. This evidence concerns the gene IFNG and autoimmune disease.