INS and type 1 diabetes mellitus: Notably, γδ T cells in NOD mice recognize processed insulin like αβ counterparts.519 Aerosolized insulin induces regulatory CD8+γδ T cells in NOD mice, preventing diabetes onset.49 Furthermore, reduced CD8+ and CD8−γδ T cells were observed in prediabetic individuals.520 A longitudinal study established the temporal association between γδ T cell percentage and the onset of T1D.