Another less well-characterized functional subset of γδ T cells that carries out regulatory functions in cancer or inflammatory diseases has been identified as γδTreg.306–311 This population is induced upon receiving Inflammatory signals in the TME and could potentially sabotage the anti-tumor phenotype of γδ T cells while reprogramming them into γδTreg.306,307,312 This subset has been identified as CD73+Foxp3+Vδ1+ T cell in the PBMC or tumor specimen of breast cancer patients313 and tumor-infiltrated CD39+Foxp3+γδT in colon cancer. This evidence concerns the gene FOXP3 and malignant colon neoplasm.