IFNG and autoimmune disease: γδT17 cells, which produce IL-17 (IL-17+γδ T cells), leading to pro-tumor and autoimmune diseases.11,16,304 Notably, γδNKT cells, which produce both IL-4 and IFN-γ, have also received increasing attention.98,112 About their development in thymus, both IFN-γ-producing subsets (γδT1 and γδNKT) has been shown to rely on strong signals from the TCRs, whereas γδT17 cells have been reported to develop even in the absence of TCR ligand selection.63,112,162,305