The unique MHC-independent recognition also offers the advantage of reduced immune rejection, rendering allogeneic adoptive γδ T cell transfer a safer therapeutic approach.11,12,587 Additionally, γδ T cells exhibit efficient APC capabilities, effectively activating other immune cells to mediate tumor clearance.56,217,632 By functioning both as tumor-specific effectors and potent APCs, γδ T cells hold significant promise in the field of immunotherapy for both hematological cancers and solid tumors. Here, HLA-C is linked to neoplasm.