For instance, γδT17 recruits immunosuppressive myeloid-derived suppressor cells (MDSCs) into the TME.76,79,80 A recent study even demonstrated that commensal microbiota could promote IL17 secretion in lung-resident γδ T cells, which then promote tumor progression.343 Interestingly, evidence indicates that the presence of γδT17 is essential for the efficacy of chemotherapy by facilitating the recruitment of IFNγ-producing cytotoxic CD8+ TILs.345 Therefore, further evidence is required to elaborate the role(s) of γδT17 in cancers. The gene discussed is IFNG; the disease is cancer.