GLS and psoriasis: For instance, our research group discovered that GLS1-mediated glutaminolysis is essential for γδT17 cell differentiation and keratinocyte proliferation, thereby contributing to the pathogenesis of psoriasis.313 Additionally, we discovered that mTOR1 and mTOR2 signaling pathways regulate the differentiation of γδT17 and are dysregulated in psoriasis-like mouse model.434 Recently, it has been shown that γδT17 cells exhibit dynamic trafficking patterns, moving to and from lymph nodes and sites of skin inflammation.436,437