Finally, we identified 45 cancer-associated proteins (CAPs) to be significantly more abundant in diagnosis specimens (n = 6) or relapse specimens (n = 12) compared to non-cancer controls (n = 3) (Supplementary Fig. S13a-d and Supplementary Data S16), including several proteins that are commonly overexpressed in acute lymphoblastic leukemias such as FLT3, CDK6, and EBF115. This evidence concerns the gene CDK6 and acute lymphoblastic leukemia.