We defined stable protein abundance between paired diagnostic and relapsed samples as a model variable for target discovery; using this criterium, and representing patient BALL01 as an example (Fig. 4b), we generated a ranked list of pan-ALL targets, which included HSPB1, PARP1, and PRDX1 as top-ranked candidates (Fig. 4c). The gene discussed is PARP1; the disease is acute lymphoblastic leukemia.