Delivery of Foxf1 to the pulmonary vascular EC23 during reoxygenation of EC-Bmpr2-/- mice resulted in the repair of DNA damage, in the restoration of angiogenesis genes required for the regeneration of normal pulmonary arteries, and in the reversal of pulmonary hypertension. The gene discussed is BMPR2; the disease is pulmonary arterial hypertension.