PROK1 and Hypertension: Previously, s-PROK1 was reported to be higher in the second and third trimesters in preeclamptic and IUGR pregnancies compared with uncomplicated pregnancies.13 14 We and others have also demonstrated that PROK1 restricts the migration and invasion of trophoblast cells in vitro, suggesting that elevated s-PROK1 impairs embryo implantation and placentation.13 18 However, s-PROK1 in the second trimester did not predict pregnancy-induced hypertension or preeclampsia in our women with PCOS.