CRP and macrophage activation syndrome: In fact, hyperferritinemia may discriminate the occurrence of MAS,41 but the mortality of these patients may be better predicted by additional features such as the multiorgan manifestations and high levels of CRP.9 28 37 41 In addition, the highest proinflammatory markers observed in these patients in cluster 3 may probably facilitate an early diagnosis and a timely treatment thus improving the outcomes.