Having confirmed the binding of AUF1 to the SNCA 3′UTR, we next examined the AUF1 functional role in SNCA mRNA expression by modulating its levels in human neuroblastoma SK-N-SH and embryonic adrenal precursor HEK293A cells, two cell lines that express high levels of endogenous SNCA mRNA and protein. Here, SNCA is linked to neuroblastoma.