GSDMD and infection: To directly address whether this epithelial GSDMD phenotype at 18 h p.i. contributes to elevated S.Tm loads in cecum tissue, and at systemic sites later during infection, we again generated BM chimeras in which we replaced the BM of GsdmD+/− and GsdmD−/− littermates with WT (CD 45.1+) BM.