GSDMA and infection: Interestingly, while Gasdermins had no impact on luminal colonization (SI Appendix, Fig. S1A), GsdmACDE−/− mice had up to 10-fold elevated S.Tm loads in mLN at 48 h post infection (p.i.)suggesting that Gasdermin(s) do restrict S.Tm gut infection (Fig. 1B).