Multivariate analysis showed that tumor burden >8 cm (HR=2.37; 95% CI: 1.564–3.593; P<0.001), pre-LT AFP >400 ng/ml (HR=1.897; 95% CI: 1.219–2.953; P=0.005), pre-LT PIVKA-II >240 mAU/ml (HR=1.558; 95% CI: 1.005–2.414; P=0.047), and tumor histopathologic grade III (HR=2.031; 95% CI: 1.291–3.194; P=0.002) were the independent risk factors for DFS (Table 2). Here, AFP is linked to neoplasm.