The pathways regulated included T cell receptor, NF-κB, B cell receptor, chemokine, PD-L1 expression in cancer and PD-1 checkpoint, Toll-like receptor, TNF, JAK-STAT, NOD-like receptor, IL-17, apoptosis, PI3K-Akt, and other pathways (Figure 4D). Here, PDCD1 is linked to cancer.