LGALS3 and Alzheimer disease: In line with our observations in human AD and FTLD brains, we detected an upregulation of Gal3 in microglia located adjacent to neurons containing misfolded tau (MC1-positive) and aggregated tau (AT100-positive) in the CA1 region of THY-Tau22 mice (Tau22; Figure 4, A–C and Supplemental Figure 10A).