TREM2 and amyotrophic lateral sclerosis: Furthermore, comparison analysis of models representing AD, amyotrophic lateral sclerosis (ALS), and multiple sclerosis showed that microglia in neurodegenerative contexts displayed elevated levels of genes associated with the Trem2-Apoe pathway, including Lgals3 and Clec7a, which contribute to the development of detrimental microglial phenotypes (18).