Interestingly, the 812 GAM genes shared 172 genes with the AD DAM genes (23) (Supplemental Figure 17A), including upregulated microglial activation genes (such as Clec7a, Cd68, Csf1, Apoe, and Cybb) and downregulated microglial homeostatic genes (such as P2ry12, TMEM119, Csf1r, Hexb, and Slc2a5). The gene discussed is APOE; the disease is Alzheimer disease.