To determine the effects of PRDM2-Δexon 2 and ARRB1-Δexon 13 isoforms on cancer cell function, we performed rescue experiments using the following groups of cancer cells: NC, AEP KD, AEP KD/tDDX3X-C res, AEP KD/PRDM2 KD, and AEP KD/ARRB1-Δexon 13 res cells (Supplemental Figure 9, A and B). Here, PRDM2 is linked to cancer.