LGMN and breast cancer: As shown in Supplemental Figure 2, D and E, in triple-negative (TN) breast cancer cells, there is a correlation between AEP activation and DDX3X cleavage, whereas in luminal A (LA), luminal B (LB), and HER-2 positive breast cancer cells, this correlation was somewhat reduced, but AEP activation and DDX3X cleavage bands were still observed under conditions of hypoxia and nutrient deprivation.