As shown in Supplemental Figure 2, D and E, in triple-negative (TN) breast cancer cells, there is a correlation between AEP activation and DDX3X cleavage, whereas in luminal A (LA), luminal B (LB), and HER-2 positive breast cancer cells, this correlation was somewhat reduced, but AEP activation and DDX3X cleavage bands were still observed under conditions of hypoxia and nutrient deprivation. The gene discussed is ERBB2; the disease is breast cancer.