VWF and Sepsis: In mouse models, intravenous histone administration provokes perturbations in the coagulation system similar to sepsis-induced consumptive coagulopathy and DIC, including endothelial damage, increased concentrations of TF and vWf, subsequently leading to PLT activation, extensive thrombosis, and coagulation factor depletion, thereby presenting as low PLT counts and prolonged PT and aPTT (2,24,34–36).