On the other hand, aberrant increases in GABA concentration and signaling in motor brain regions have been associated with motor disturbances in the context of other neurological disorders [90, 91] and in the context of Foxp2 loss-of-function paradigms [25, 29, 30, 92] suggesting a potential activation/inhibition imbalance in R6/1 mice since striatal glutamate levels are changed to a lesser extent. The gene discussed is FOXP2; the disease is nervous system disorder.