To test whether lowering of Foxp2 levels in thalamic neurons of WT mice could mimic the HD motor-sensory disturbances, we transduced the ventrobasal thalamus of 11-week-old WT mice with an AAV expressing a shRNAFoxp2 (shFoxp2 group) or with an AAV expressing a scramble construct (Scramble group) (Fig. 8a–e). This evidence concerns the gene FOXP2 and Huntington disease.