Although neither MSP nor PSP is likely to achieve the enzymatic processing of SARS-CoV-2 with the efficiency of the TMPRSS2 interaction, this inefficiency may actually be the source of a tangible host-protective effect, such that sustained complexation with the pathologically critical Spike C-terminal cleavage product may impair the capacity of SARS-CoV-2 virions to inflict infection and compromise host lymphocyte response [235]. Here, TMPRSS2 is linked to infection.