Finally, as a converse example, SERPINE1/PAI-1 overabundance seems to correlate strongly with both severe non-infectious respiratory pathology [141,148,149,150] and a propensity to foster coagulopathic outcomes in severe COVID-19 cases, including interrelated acute respiratory distress syndrome (ARDS) and thrombotic manifestations [151,152,153], through apparent impairment of fibrinolytic activity [151]. The gene discussed is SERPINE1; the disease is acute respiratory distress syndrome.