ABCD1 and adrenomyeloneuropathy: ALDP deficiency manifests primarily with three clinical phenotypes: (a) isolated primary adrenal insufficiency (PAI), (b) myelopathy with or without peripheral neuropathy (adrenomyeloneuropathy, AMN), and (c) progressive inflammatory white matter demyelination cerebral form, which includes childhood cerebral ALD (CCALD) and adolescent cerebral ALD (AdolCALD) [19].