Chr 4: Small nucleolar RNA host gene 12 is an oncogene that promotes tumor formation through cell cycle, invasion, metastasis, and apoptosis. It also affects the Wnt-β-catenin and MLK3/IκB/NF-κB pathway, Notch-1 signaling pathway, and PI3K/AKT pathway, and serves as a competing endogenous RNA (ceRNA), similar to a miRNA sponge, wherein it attenuates the effects of miRNAs, often leading to cancer progression. This evidence concerns the gene NOTCH1 and cancer.