Additionally, the downregulated DE-mRNAs, such as TGFB2, DST, OLR1, GEN1, RASA2, FOXO1, JMJD1C, ROCK1, and WNT5A, have been previously associated with breast cancer as biomarkers [92,93,94,95] and therapeutic targets [96], or by participating in several processes such as metastasis [62,97,98], apoptosis [99], chemosensitivity [99], and epigenetic changes [100]. The gene discussed is GEN1; the disease is breast cancer.