SDC1 and breast carcinoma: For instance, it has been shown that the downregulation of SDC1 mediated by hsa-mir-122-5p or liver-cell-derived exosomes would significantly augment the migratory capacity of breast cancer cells; furthermore, the metastatic potential or mobility of breast cancer cells is probably influenced by the presence of circulating hsa-mir-122-5p, which may not be directly correlated with the progression of breast cancer [120].