In a non-conventional approach, a preclinical study reported the use of a TCR mimic against the peptide–HLA complex to target Preferentially Expressed Antigen in Melanoma (PRAME), which is expressed by several AML cell lines, primary AML, and other malignancies but has restricted expression in cells of normal hematopoiesis and is referred to as cancer testis antigen [105]. Here, PRAME is linked to acute myeloid leukemia.