The convincing evidence manifested that NANOG has a crucial role in self-renewal and differentiation of stem cells, and it could be responsible for the oncogenic process.25 Bao B et al26 previously showed that PCa cells, PC3 and LnCap, increase the level of IL-6 and vascular endothelial growth factor in hypoxic conditions that affect CSCs and increase the level of NANOG gene. The gene discussed is IL6; the disease is posterior cortical atrophy.