Recently, it has been demonstrated that there is a strong link between NANOG gene and IL-6 signaling in esophageal squamous carcinoma, as NANOG is one of the downstream regulators of STAT3.30 Therefore, we think that the same mechanism could be responsible for PCa stemness, as NANOG promotes the formation of PCa stem cells in an IL-6-rich environment that can be considered as a crucial factor for tumor aggressiveness. This evidence concerns the gene STAT3 and neoplasm.