In the case of MED12-dependent leiomyomas, this function could be carried out by the membrane proteins POPDC2, PLP1 (proteolipid protein, lipofilin, expressed in the central nervous system, responsible for the interaction of axon membranes with myelin), THSD4 (Adamtsl6-β-transmembrane protein 4 with thrombospondine domain). Here, THSD4 is linked to leiomyoma.