Holzmann et al., 2014 [28] reported that leiomyoma foci without somatic mutations in the MED12 gene nor overproducing HMGA2 are prone to so-called chromotripsis (multiple duplications and deletions of small segments grouped mainly into five chromosomal regions 2p14 - 2pter, 2q33.1 - 2q37.3, 5q31.3 - 5qter, 11q14.1 - 11qter, and 18p11.21 - 18q2.3). Here, MED12 is linked to leiomyoma.