CHEK1 and prostate adenocarcinoma: Interestingly, compared to prostate adenocarcinoma, CHK1 mRNA was markedly upregulated in NEPC tumors (p = 7.299E-4), while that of WEE1 was not (p = 0.398) (Fig. 1F)., The expression of CHK1 mRNA was positively correlated with the expression of WEE1 mRNA in NEPC (Spearman’s r = 0.6, p = 4.65E-6), but not in prostate adenocarcinoma (Spearman’s r = −0.13, p = 4.944E-3) (Fig. 1G).