NFKB1 and amyotrophic lateral sclerosis: “In conclusion, while Nakazawa et al. (2016) demonstrated a clear relationship between OPTN and NF-κB activation in the context of ALS, the findings of Slowicka et al. (2016) and Munitic et al. (2013) suggest that the role of OPTN in NF-κB signaling may be more complex and context-dependent”.