Behavioral symptoms in AD in relation to frontal cortex are relevant to a previously described variant labeled executive, or behavioral variant AD.41–47 Comparisons between typical amnestic AD and behavioral variant AD point to divergent patterns of cortical atrophy,41,42 glucose metabolism,43 and tau accumulation.48 However, these studies have limitations such as not including measures of behavior or considering both hemispheres simultaneously. The gene discussed is MAPT; the disease is Alzheimer disease.