Furthermore, the IL4I1/IDO1/AHR axis promotes tumor progression and aggressiveness26–30 which is consistent with our Gene Set Enrichment Analysis (GSEA) indicating that mutant Δ133p53α R273H overexpression correlates with increased inflammatory response and epithelial-to-mesenchymal transition (EMT) (Supplementary Fig. 1M). The gene discussed is AHR; the disease is neoplasm.