With the status of glucose metabolism worsening, the subjects got older, and the levels of BMI, WC, hip circumference, SBP, DBP, FPG, TG, ALT, AST, Scr, and CIMT increased as well as the prevalence of obesity, hypertension, dyslipidemia, and carotid plaque, whereas the level of HDL‐C decreased. Here, GPT is linked to obesity due to melanocortin 4 receptor deficiency.