However, early clinical studies suggest that the AKT/mTORC1 pathway may also be mis-regulated in old human muscles [117,118], possibly with low efficiency of AKT signalling [117] and increased basal levels of phosphorylated mTORC1 and its downstream target S6K1 [118], these data being consistent with evidence in rodent sarcopenia. Here, AKT1 is linked to sarcopenia.