In this study, we found that adoptive transfer of the purified CD8+ T cells from the mice that had been vaccinated with GPC3144‐152 peptide and treatment with the peptide significantly inhibited the growth of TYST tumors by increasing granzyme B‐secreting CD8+ T cells and the frequency of TUNEL+ apoptotic tumor cells in vivo. The gene discussed is GZMB; the disease is neoplasm.