Together, the results indicate that tumor cell cytosolic detection of DNA by cGAS catalyzes the generation of 2′–5′ cyclic GMP‐AMP (cGAMP), which binds to STING, allowing it to recruit, phosphorylate, activate TBK1 and IRF3, and produce Type I IFNs. The gene discussed is STING1; the disease is neoplasm.