Interestingly, GPC3, either a tumor suppressor or an oncofetal protein, can stimulate or inhibit cell proliferation, depending on its relevant signaling pathways,10, 39 and the decreased GPC3 expression may reflect tumor cell death or activating the cGAS/STING signal‐dependent TNF‐mediated necroptosis,40 or reprogramming of TYST cells caused by changes in the TME.41, 42, 43. The gene discussed is GPC3; the disease is neoplasm.