The enhanced TBK1 and IRF3 activation should increase the sensitivity of TYST cells to CD8+ T‐cell‐mediated killing in the co‐culture system while cGAS silencing usually attenuated the cGAS‐STING signaling to reduce IFN‐β production and CD8+ T‐cell infiltration, promoting tumor growth.51 This evidence concerns the gene IRF3 and neoplasm.