It progresses rapidly and can lead to serious complications and even long-term disability.[1] The most common treatment for IS is intravenous thrombolysis using recombinant tissue plasminogen activator; however, the window for treatment is only 3 hours.[4] Thus, it is crucial to determine the causes and underlying molecular mechanisms of stroke, identify molecular biomarkers for early diagnosis, and develop precise preventive treatments.[5]. This evidence concerns the gene PLAT and Stroke.