Recently, several TRPs were reported highly overexpressed in invasive ductal carcinoma, for example TRPC6, TRPM7, TRPM8, TRPV6 and TRPC1.[46,47] As such, TRPs were proposed by some scholars to be play as novel biomarkers for BC diagnosis and treatment. The gene discussed is TRPM8; the disease is invasive ductal breast carcinoma.