NR3C1 and post-traumatic stress disorder: Over-generalized fear is one of the main symptoms of anxiety and PTSD, but overgeneralized fear can be eliminated by blocking cholinergic muscarinic receptors, which maybe an excellent treatment for PTSD and anxiety.[46,47] Glucocorticoid receptors (NR3C1) are widely expressed in the hippocampus, amygdala, and prefrontal cortex and are involved in encoding, retaining and processing information about emotional events.