Furthermore, a recent study investigating the association between CRS and GC sensitivity found that compared to the normal control group, the expression of GRα and the GRα/GRβ ratio in peripheral blood mononuclear lymphocytes (PBML) of patients with different types of CRS decreased.[84] Several studies have demonstrated that the expression of GRα mRNA significantly decreases in nasal polyps after GC treatment, while that of GRβ mRNA remains unchanged,[83] suggesting that GRα may play a more significant role in nasal polyp-related inflammation. This evidence concerns the gene GZMB and Nasal polyposis.