Additionally, some studies have also indicated that the enhanced expression of GRβ under disease conditions is often accompanied by GC resistance or insensitivity.[11,79] Similarly, researchers have observed that the upregulation of GRβ expression in the glaucoma trabecular meshwork cells in glaucoma leads to increased resistance, while its downregulation results in increased GC sensitivity.[85]. This evidence concerns the gene GZMB and glaucoma.