NFKB1 and chronic rhinosinusitis with nasal polyps: The activation of the NF-κB/miR-155 signaling pathway regulates the expression pattern of cytokines, ultimately modulating the inflammatory response.[93] To summarize, NF-κB activation is known to increase miR-155 expression in CRSwNP, ultimately resulting in changes in the expression of downstream inflammatory cytokines and the development of GCR.