The activation of the NF-κB/miR-155 signaling pathway regulates the expression pattern of cytokines, ultimately modulating the inflammatory response.[93] To summarize, NF-κB activation is known to increase miR-155 expression in CRSwNP, ultimately resulting in changes in the expression of downstream inflammatory cytokines and the development of GCR. This evidence concerns the gene NR3C1 and chronic rhinosinusitis with nasal polyps.