NR3C1 and chronic rhinosinusitis with nasal polyps: Milara et al[130] found that in GC-resistant CRSwNP patients, the expression of MUC1 was reduced, and there was a decrease in the formation of the GRα complex and an increase in serine residue phosphorylation at the GRα 226 site, which ultimately resulted in reduced nuclear translocation of GR and anti-inflammatory effects, leading to GCR.