NFKB1 and chronic rhinosinusitis with nasal polyps: The formation of CRSwNP involves numerous transcription factors, including but not limited to nuclear factor-kappa B (NF-κB), activator protein-1 (AP-1), and signal transducer and activator of transcription (STAT).[87–90] These transcription factors play a key role in regulating the expression of T cells and other related inflammatory genes, thereby serving as a crucial factor in the development of GCR.