Increased carbohydrate intake can interfere with ALAS1 transcription and inhibit the accumulation of related products in the body, thereby improving symptoms.[16] Glucose can also stimulate insulin secretion, directly inhibiting ALAS1 expression.[17,18] In the acute phase of AIP attacks, a high-carbohydrate diet (300–500 g/d) is recommended. This evidence concerns the gene INS and autoimmune pancreatitis.