CD34 and brain inflammatory disease: Experimental autoimmune encephalomyelitis (EAE) is a common inflammatory disease of the brain, and the expression of CD34+ in TCs was found to be significantly upregulated in the spleen of mice with EAE, and CD34+ TCs were shown to be involved in the regulation of immune response after spleen injury, specifically by recruiting of macrophages and proliferating stem cells and promotings tissue repair and regeneration in mice with EAE.