AVP and autosomal dominant polycystic kidney disease: The PREVENT-ADPKD trial, a 3-year trial evaluating effects of high water intake, failed to show benefits for total kidney volume (TKV), eGFR, and other end points.11,12 Only 52% of the participants assigned to high water intake achieved the target Uosm of 270 mOsmol/kg.12 There were no differences in TKV progression or serum copeptin in this trial between the high or ad libitum water intake groups.