Reactive microglia in CK-p25 mice (which overexpress the cyclin-dependent kinase 5 cleavage product p25 in the postnatal forebrain, triggering AD-like neurodegeneration, atrophy, gliosis, and phosphorylation of endogenous tau [14]) have been grouped into type I and type II interferon-responsive phenotypes [15]. This evidence concerns the gene MAPT and Alzheimer disease.