Similar as what were observed in in vitro cultures (Fig. 3), tumor tissues with NEAT1-overexpression showed overall more expressions of Sema4D, Plexin B1, Tiam1, and Rac1/2/3 proteins than the control tumor tissues, although no significant differences in protein levels of Plexin B1 from SKOV-3 xenograft (Fig. 4F) and Rac1/2/3 from both SKOV-3 xenograft (Fig. 4F) and A2780 xenograft (Fig. 4G) were identified. This evidence concerns the gene TIAM1 and neoplasm.