Blank cells without gene expression manipulation, and the cells after transfection of NEAT-1-expressing plasmid, or infection of NEAT1-specific shRNA-expressing lentivirus, as well as the NEAT1-overexpressing cells upon further transfection of miR-214-3p mimics, were subjected to western blot analysis (Fig. 3A, B) for quantitating the protein levels of Sema4D, Plexin B1, Tiam1, and Rac1/2/3. The gene discussed is SEMA4D; the disease is infection.