BACE1 and colorectal carcinoma: To explore the BACE1-AS regulated signaling pathways involved in CRC liver metastasis, we acquired microarray dataset GSE224235 compering the matched primary and liver metastatic lesions, and identified several signaling pathways regulating pluripotency of stem cells were critical for CRC liver metastasis, among which was Wnt signaling pathway (Fig. 6A-B).