Expression of renal tubular ACE2 and MasR has been reported to be increased in a mouse model of lipopolysaccharide (LPS)-induced AKI, suggesting possible activation of the ACE2/Ang-(1–7)/MasR axis during sepsis [54], a hypothesis that should be interpreted with caution as high enzyme concentrations (ACE) are not necessarily associated with increased enzyme activity [48]. Here, ACE2 is linked to acute kidney injury.