To dissect whether ZNF488 regulates cell death of pancreatic cancer cells, we stained the pancreatic cancer transfected with siCtrl or siZNF488 with PI and Annexin V. Flow cytometry analysis showed that ZNF488 knockdown moderately enhanced the percentage of Annexin V positive cells (Fig. 3A, B). The gene discussed is ANXA5; the disease is pancreatic neoplasm.