Simultaneously, TNFα is a proinflammatory cytokine related to innate immune response, which is related to a variety of neurodegenerative diseases including Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, ischemic brain injury, etc., and is considered to be one of the important indicators of the severity of IS [32, 33]. This evidence concerns the gene TNF and early-onset autosomal dominant Alzheimer disease.