SII and AISI as inflammatory indicators may regulate the activity of inflammatory cells in a variety of ways, and studies have found that the elevation of SII and AISI is associated with the increase of pro-inflammatory factors (e.g., tumor necrosis factor-alpha, interleukin-6, etc.)and inflammatory mediators [26, 27], thereby promoting the occurrence and development of thyroid nodules. This evidence concerns the gene TNF and thyroid nodule.