CD274 and cancer: For example, aspirin could manipulate the miR-98/WNT1 axis to inhibit cancer progression [33]; it could also suppress the growth of cancer cells via targeting the TAZ/PD-L1 axis [34]; in addition, other NSAIDs like ibuprofen could enhance the effect of cisplatin by suppressing the heat shock protein 70 [13], and acetaminophen could promote ferroptosis by regulating Nrf2/heme oxygenase-1 signaling pathway [35], and loxoprofen sodium could inhibit tumor growth by suppressing vascular endothelial growth factor in a mouse model [36].