Interestingly, some NSAIDs like aspirin could not only cancel the pro-tumorigenic effects of IL-6 [58] but also downregulate the IL-6-STAT3 signaling pathway to induce cancer cell apoptosis, which have been validated in colorectal cancer [59] and glioblastoma A172 cells [60]. This evidence concerns the gene STAT3 and glioblastoma.