Research on the C-X3-C motif chemokine ligand 1-C-X3-C motif chemokine receptor 1 (CX3CL1-CX3CR1) axis, which may be linked to the advancement of LC, shed light on the function of miR-200a–3p. The gene discussed is CX3CL1; the disease is laryngotracheoesophageal cleft.