Notably, among 184 differentially mutant genes, CRC driver genes CTNNB1 (p = 1.41E−03), MUC16 (p = 8.00E−03), and the gene encoding DNA polymerase epsilon (POLE; p = 1.39E-02; Fig. 3E) had significantly higher frequency of mutation in high-risk EOCRC. Here, POLE is linked to colorectal carcinoma.