In addition, the mRNA expression of IL-1 receptors, IL-1R1 and IL-1RAcp (Minna lab dataset, dbGaP Study Accession is phs001823.v1.p1), and response to IL-1β stimulation, which was measured as fold change in CXCL8 induction, were detected in immortalized normal cells and lung adenocarcinoma cells (Table 1 and Supplemental Fig. 1A). Here, IL1B is linked to lung adenocarcinoma.